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| Resveratrol Analyzed: Does it Live Up To The Hype? |
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The Benefits Of Resveratrol!
It must be clear that majority of the
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Guide to Resveratrol
Nowadays,
all anyone in the medical, cosmetic, and healthcare industries can talk about is
the newest panacea formula to hit the mainstream: Resveratrol. If you haven't
been keeping abreast with the latest scientific studies then you've likely overlooked the culmination of all the modern reports on
this miracle medicine. If you have been keeping tabs and you're already aching
to get some Resveratrol "magic" yourself, then you've likely seen the latest
articles and columns found in publications like CNN and the Mayo
site or watched the interviews from shows like Oprah and 60 Minutes.
History
and Timeline of Resveratrol Research
Resveratrol,
otherwise known as trans-Resveratrol, is a biologically produced
Phytoalexin
created by certain plant life whenever they're assaulted by pathogens like fungi
or bacteria. Resveratrol has been successfully synthesized by scientists and is
currently available as a nutritional supplement procured mainly from Japanese
knotweed. It is also found in red grape skin and is one of the many ingredients
of red wine.
In certain
experiments involving rats and mice as test subjects, more than a few beneficial
Resveratrol effects involving cardiovascular/blood sugar/inflammation/cancer
management has been observed. Moreover, in the only positive human trial for the
drug thus far, sizeable doses of resveratrol (about 3 to 5 grams worth) in a
propriety product has shown to appreciably decrease blood sugar content in
people.
-
Cancer
Application:
In 1997,
a scientist named Jang and his team of researchers reported that using
Resveratrol as a topical agent can prevent skin cancer progression in mice
treated with a carcinogen. Also, there have been a multitude of reports
concerning the anti-cancer ability of Resveratrol in other animal species.
Clinical trials are presently being conducted in regards to resveratrol
effects on melanoma and colon cancer in humans.
-
Lifespan
Increase in Yeast, Fruit Flies, and Worms:
In 2003,
the groups of Sinclair and Howitz disclosed to the journal "Nature" that
Resveratrol significantly extends the lifespan of a certain species of yeast
(Saccharomyces cerevisiae). Later tests by the Sinclair group demonstrated
Resveratrol's ability to also lengthen the lifespan of certain species of
fruit fly (Drosophila melanogaster) and worm (Caenorhabditis elegans).
-
Lifespan
Increase in Short-Lived Fish:
In 2006,
the inevitable resveratrol experiments on non-invertebrate animals led to
the first positive result of supplementation on a vertebrate care of several
Italian scientists. The authors used a short-lived fish (Nothobranchius
furzeri) that typically lives for nine weeks, and were able to increase its
lifespan by 56%. Compared to the control fish, the supplemented fish learned to avoid painful stimulus quicker and had higher swimming-related activity. Because of the slight increase in death of young fish caused by resveratrol, the Italian researchers conjectured that it was the fish's weak toxic action that activated its defense mechanisms and caused the lifespan prolongation.
-
Duplicated Results and Mice Experimentation:
In 2007, a different team of
researchers were able to duplicate Sinclair's earlier experiments with
Caenorhabditis elegans, but yet another group of researchers failed to
achieve consistent increases in lifespan of either species of worm or fruit
fly. Later in the same year, Sinclair announced that resveratrol offset the
harmful effects of high-fat diet in mice, which could potentially prove
useful in counteracting obesity in humans in the near future. The mice's diet was worsened by adding coconut oil to their food; the increase resulted in a 60% rise of energy from fat, which made the mice eat about 30% more calories than the control mice that were on a customary diet. A joint study by another group of researchers and the Sinclair group demonstrated that resveratrol therapy had a variety of helpful outcomes in elderly mice but wasn't able to increase the lifespan of fattened mice when the treatment is commenced in midli
Most
Significant Resveratrol Benefits
Resveratrol
is believed by many experts and healthcare professionals to assist in three
major health issues: neurodegenerative sicknesses, cancer prevention, and life
extension or aging delay. The chemical is also known to improve overall health
and has many other medical benefits to boot. Here are all five benefits
presented in further detail:
-
Life
Extension:
Resveratrol was first documented in 2006 to successfully decrease the
physical symptoms of aging and significantly increase life outlook. The
formula was considered an anti-aging agent after Italian scientists
concluded that, when taken at a young age, it produced a rise in life
outlook. Further studies in the last three years have also come up with the
same conclusion, thus solidifying Resveratrol's properties when it comes to
diminishing the physical manifestation of aging.
-
Cancer
Prevention:
As
mentioned earlier, experts have reported way back in 1997 that Resveratrol
is a viable method in preventing cancer. The basic conclusion experts agree
upon about Resveratrol is that it can assist in hampering cancer formation
when in contact with a tumor and the like. To be more specific, Resveratrol
animal tests on stomach and skin cancers have proven to be successful, or at
the very least promising.
-
Neurodegenerative Sickness Therapy:
Just
last year, a Weill Medical School study at Cornell showed that Resveratrol
can assist in decreasing plaque formation in the brain. This implies
beneficial applications in the realm of Alzheimer's disease treatment and
therapy for many other neurodegenerative sicknesses.
-
Healthier Way of Life:
To the
computer savvy people out there, Resveratrol can be compared to the
"defragment" function of your computer. It basically helps make your body
become healthier and more efficient at maintaining itself, hence its
life-prolonging abilities. By taking regular doses of this supplement,
you'll be able to prevent getting health problems before they even occur.
-
A
Panacea in Every Sense of the Word:
A researcher who helped perform
tests on resveratrol's efficacy once claimed that he and his team may have
found a true cure-all drug. With the right administration and with the
correct complement of medicines, the substance could indeed enable cures for
any ailments in the body without harming uninfected or innocent cells.
Pharmacokinetics and Proper Dosage Of Resveratrol
The most
effective method of dosing humans with Resveratrol appears to be buccal
delivery; i.e., complete absorption of the chemical through the inside of a
person's mouth without swallowing. When one milligram of the chemical in a fifty
milliliter solution was held inside the mouth of a test subject for one minute
before ingestion, free resveratrol amounting to 37 nanograms per milliliter was
measured in his blood just a couple of minutes later. In pill form, you need to
take about 250 milligrams worth in order to get the same level of unchanged
Resveratrol in your blood plasma. About 70% of
Resveratrol is absorbed when administered orally in pill form. However, the
agent's oral bioavailability is rather low because it is easily metabolized in
your liver and intestines into two conjugated forms: sulfonate and glucuronate.
Only trace amounts (below five nanograms per milliliter) of unaltered
Resveratrol can be found in the bloodstream after a mere 25 milligram dose.
On that
note, here are the three different possible resveratrol dosages in pill form:
-
Low
Resveratrol Dosage:
Ranges
from 100 to 500 milligrams taken daily.
-
Medium
Resveratrol Dosage:
Ranges
from 500 to 1,500 milligrams taken daily.
-
High
Resveratrol Dosage:
Anywhere
above 1,500 milligrams taken daily.
These
dosages are rather controversial when discussed by different experts and medical
professionals. How much of a given Resveratrol supplement should a person take
is best left in the hands of your designated healthcare specialist or physician;
this is because there are many other factors you need to consider when talking
about proper dosage, so nobody knows what's the right dose for you save for your
doctor.
Also
remember that it's essential for you to let your doctor know about your medical
history or allergies to specific drugs in order to avoid mixing Resveratrol with
anything that could cause you harmful side effects.
The Future
of Resveratrol
This
naturally occurring substance is truly making the headlines nowadays. Provided
that it lives up to its potential, it could very well prove to be the discovery
that changes the course of medical research forever. Truly, ever since test
results showed Resveratrol's huge impact on the human body and human health in
general, scientists have been working around the clock for other possible
applications in which the beneficial supplement can be used on.
At this
point, many corporations are scrambling to create a number of prescription
products containing significant traces of the special substance. Many people
believe that the discovery of Resveratrol's health benefits is mankind's most
important innovation since the invention of the telephone or even the Internet.
In addition, future research will probably tackle key medical issues like
stroke, heart disease, and so on based on their impending findings concerning
Resveratrol's therapeutic properties.
HGH With Resveratrol
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