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How HGH Is Made? |
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Understanding
HGH Made from Recombinant DNA
About thirty years ago, in the latter portion of the 1970s,
researchers began focusing in on rhGH, better known as human growth hormone made
with recombinant DNA. The research initially started in order to find a better
way of obtaining human growth hormone. The main method used at that time
involved extracting the protein from the pituitary glands of corpses. Some of
this human growth hormone was contaminated. Evidence soon emerged that it
could, at the very worst, lead to very deadly neurological problems. Some of
the same companies and researchers who had been fundamental in developing human
insulin were on board to find a better way of attaining human growth hormone.
Howard Goodman was one of the primary individuals at the forefront of the
discovery which lead to cloning the rhGH gene found in bacteria. This occurred
in 1979. By 1985, Genentech was responsible for marketing the rhGH used to help
children who had human growth hormone deficiencies. A year later, in 1987, Eli
Lilly did the same.
As with most innovative medical technologies, there were
controversies and problems. Just ten years ago, Genentech was sued by, and paid
a settlement to, the University of California. The suit was for patent
infringement, involving Protropin.
There are currently a number of rhGH products on the
market, specifically produced by microbes. They are considerably more
affordable than they used to be and they are available in many different forms,
including those which can be taken orally. Because it is now possible to
produce HGH and rhGH in mass quantities, there are also plenty of products
available. This, too, makes it easy to sell the products at less expensive
prices than the majority of their forebears.
Until very recently, the FDA had only approved rhGH and
human growth hormone to be used for children with human growth hormone
deficiencies. However, it was also approved for use in adults in 1996;
specifically, adults who have pituitary diseases, or hormone deficiencies.
Since that time, many controversies have emerged; in fact, many people have a
number of ethical questions regarding this approval. One question many people
have is whether or not rhGH should be allowed to be used in children who are
short of stature but who do not have hypopituitarism. A lot of parents who have
short children seek the benefits of these drugs. Sometimes they do this simply
so their children can receive a fairer shot in their futures, since there have
been studies which suggest that one's income can be determined by one's height.
Furthermore, human growth hormone and rhGH has been proven to build up and
improve muscle mass. Thus another ethical question pertains to athletes, and
whether or not they should be allowed to take the drug to improve their
performance. As most people know, there have been a number of Olympic
controversies wherein athletes have been proven to be taking steroids -- but
what of rhGH? Naturally, too, many people are concerned about the possibility
of health risks, especially long term ones.
Ever since the middle of the twentieth century, HGH supplements of some type have been around. The technology has
come a long way since Human growth hormone was obtained from cadavers. At the time, it was the
only available HGH for treating people with dwarfism and other growth
deficiencies. Cadaver based HGH proved to be dangerous as many patient using it
developed Creutzfeldt Jacob disease. Fortunately, nowadays, while still
expensive the risks of getting infected from HGH has become practically non
existent. Additionally with the
availability of HGH supplements such as
Cloud Nine HGH, Provacyl, Genfx, Z-tropin, GHR1000, Genf20 Plus, Rejuvenate 2000 and Sytropin one could start HGH therapy without
worrying about the side effects that usually come with using HGH injections.
A List Of HGH Supplements
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